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This content does not have an English version. Seizure development may be related to the rate of rise in hematocrit, which is also associated with blood pressure elevations. Keep all medical and lab appointments. darbepoetin alfa can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Consult your doctor for more details. When used to treat anemia related to cancer, darbepoetin alfa may also increase the risk of death and/or cause your tumor to grow faster. Before using darbepoetin alfa, tell your doctor or pharmacist if you are allergic to it; or to other drugs that cause more red blood cells to be made (such as epoetin alfa); or if you have any other allergies. Follow your doctor's instructions and dietary recommendations. "Product Information. Keep all medications away from children and pets. This can be life-threatening and requires immediate medical attention. Erythropoietin interacts with progenitor stem cells to increase red cell production.

This medication is very similar to the natural substance in your body (erythropoietin) that prevents anemia. Bone marrow problems (eg, hemolytic anemia, sickle cell anemia, porphyria, thalassemia)—Use of darbepoetin alfa injection has not been established in patients with these conditions. We comply with the HONcode standard for trustworthy health information -, Drug class: recombinant human erythropoietins, Anemia Associated with Chronic Renal Failure. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The use of erythropoiesis-stimulating agents is contraindicated in patients with uncontrolled hypertension. Darbepoetin alfa drug interactions (in more detail). Follow your doctor's instructions very carefully. Call your pharmacist for new medicine. Drug interactions may change how your medications work or increase your risk for serious side effects. Procrit (epoetin alfa)." If any of these effects last or get worse, tell your doctor or pharmacist promptly.

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. There are 4 disease interactions with darbepoetin alfa which include: seizures; hemodialysis; hypertension; thrombotic events Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The dosage is based on your medical condition, weight, and response to treatment. Highly clinically significant.

Consult your doctor for more details. increased blood pressure--severe headache, blurred vision, pounding in your neck or ears, anxiety, nosebleed. (1990): 46, Lago M, Perezgarcia R, Devinuesa MSG, Anaya F, Valderrabano F "Efficiency of once-weekly subcutaneous administration of recombinant human erythropoietin versus three times a week administration in hemodialysis patients." (1992): 277-82, Flaharty KK, Grimm AM, Vlasses PH "Epoetin: human recombinant erythropoietin." Amgen, Thousand Oaks, CA. Aggressive antihypertensive measures may be necessary, particularly early on in treatment when the hematocrit is increasing. Ortho Biotech Inc, Raritan, NJ. Patients with epilepsy or predisposed to seizures should be monitored closely for blood pressure changes and neurologic symptoms during therapy with these agents. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself. There are 4 disease interactions with Aranesp (darbepoetin alfa) which include: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Int J Artif Organs 17 Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Darbepoetin alfa may also shorten remission time or survival time in some people with certain types of cancer. We would like to show you a description here but the site won’t allow us. Darbepoetin alfa may also be used for purposes not listed in this medication guide. There are 4 disease interactions with darbepoetin alfa: Major Potential Hazard, Moderate plausibility.

This is not a complete list of side effects and others may occur. Subscribe to Drugs.com newsletters for the latest medication news, alerts, new drug approvals and more. kidney disease (or if you are on dialysis); Tell your doctor if you are pregnant or breastfeeding. Call your doctor for medical advice about side effects. Darbepoetin alfa is used to treat anemia caused by chemotherapy or chronic kidney disease. Your blood pressure should be checked often. Nephron 63 Do not start, stop, or change the dosage of any medicines without your doctor's approval. Selected from data included with permission and copyrighted by First Databank, Inc.

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(1993): 113-4, Eschbach JW, Abdulhadi MH, Browne JK, Delano BG, Downing MR, Egrie JC, Evans RW, Friedman EA, Graber SE, Haley NR, et al "Recombinant human erythropoietin in anemic patients with end-stage renal disease.

Bennett WM "Side effects of erythropoietin therapy." Tell your doctor if your symptoms do not get better or if they get worse. Consult your pharmacist or local waste disposal company.Information last revised October 2017. Follow state or local laws about how to dispose of this container. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Applies to: hemodialysis. Before using this medication, tell your doctor or pharmacist your medical history, especially of: high blood pressure, heart disease (such as heart failure, past heart attack/stroke), seizure disorder, severe anemia caused by antibodies to past erythropoietin-type treatment (pure red cell aplasia). Nephron 72 Get medical help right away if you have: shortness of breath/rapid breathing, chest/jaw/left arm pain, unusual sweating, confusion, sudden dizziness/fainting, pain/swelling/warmth in the groin/calf, sudden/severe headaches, trouble speaking, weakness on one side of the body, sudden vision changes, blood clots in your hemodialysis vascular access site. In these cases, your doctor may want to change the dose, or other precautions may be necessary. You must know how to properly measure a full or partial dose of darbepoetin alfa.

Tell your doctor right away if you have any serious side effects, including: symptoms of heart failure (such as shortness of breath, swelling ankles/feet, unusual tiredness, unusual/sudden weight gain). Let the medication come to room temperature before using. Subscribe to Drugs.com newsletters for the latest medication news, alerts, new drug approvals and more. Other drugs may affect darbepoetin alfa, including prescription and over-the-counter medicines, vitamins, and herbal products. There are 18 drug interactions with darbepoetin alfa. Applies to: Seizures, Renal Dysfunction. See our safe care and visitor guidelines, plus trusted coronavirus information. List Darbepoetin Alfa-Albumin Solution side effects by likelihood and severity. Results of a phase III multicenter clinical trial." You may report side effects to Health Canada at 1-866-234-2345. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Follow your doctor's instructions about any restrictions on food, beverages, or activity. Binding of erythropoietin to the erythropoietin receptor leads to receptor dimerization, which facilitates activation of JAK-STAT signalling pathways within the cytosol. Am J Kidney Dis 18 Before using, check this product visually for particles or discoloration. Do not shake; vigorous shaking may denature darbepoetin alfa, rendering it biologically inactive. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Aranesp® (darbepoetin alfa) is used to treat a lower than normal number of red blood cells (anemia) caused by chronic kidney disease in patients on dialysis and not on dialysis and anemia caused by chemotherapy that will be used for at least two months after starting Aranesp®. Data sources include IBM Watson Micromedex (updated 1 Oct 2020), Cerner Multum™ (updated 1 Oct 2020), Wolters Kluwer™ (updated 30 Sep 2020) and others. Ask your doctor if you should learn how to check your own blood pressure. All rights reserved.

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