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Leo is admitted with heroin in his system and is in withdrawal.

"[161] When a 2011 storyline featured Frieda facing redundancy, Simon commented, "we would be gutted if she left.

In 2007, the show moved to Thursday nights to allow HolbyBlue to be shown in the 8pm Tuesday timeslot. On the day before Tara's operation, they get married in front of Tara's parents and their friends and co-workers, Elliot Hope, Jac Naylor, Jonny Maconie and Mo Effanga at Holby hospital gardens. "[26]

Holby City follows the professional and personal lives of medical and ancillary staff at Holby General. Holder has stated that there is a possibility Thandie may return in the future, revealing that she did not expect to return for the show's twelfth series, so could be invited back again.[196].

Quarshie explained that upon Thandie's return, Ric initially believes her to be a "terrible person", however ultimately realises that he has been allowing his emotions to interfere with his work, and when Thandie correctly diagnoses a patient, he is impressed to realise that he has underestimated her medical ability. Diane accepts the offer, but that evening parks the car on a railway line and commits suicide. Holby City has been compared to other medical dramas, often unfavourable. John Michie began playing Guy Self on 26 November 2013.

Berenice "Bernie" Wolfe, played by Jemma Redgrave, made her first appearance during the series eighteen episode "Serenity" on. Tom can't commit to Anita and she may take the job she has been offered in the USA. Ian Curtis plays staff nurse Ray Sykes, who appears from the first episode of Holby City until series two, episode 16.

[167] Dhillon describes his character as: "kind of the counterpoint to Ric Griffin. Professor John Gaskell is certainly going to be an interesting character and I can't wait to get started on the wards. [47] Series producer Kate Hall commented that Nicky's friendship with Meena would be "sorely tested".

Zubin questions the methods of an "old school" surgeon who he thinks is incompetent. [113] Her arrival sees Sacha Levy looking for a new doctor to replace Dr. Penny Valentine who had previously been killed off on the show. [47] Both Nicky and Meena struggle to impress Jac Naylor (Rosie Marcel) and keep up with the pace of their rotation. [180] The role of Dean was created specifically for Henshall, who describes the character as: "cheeky but kind hearted. However, Jayne is successful in keeping the immigrant Tan family at Holby to have their baby rather than being deported back to a nation where they would be killed. Following her appointment, the new Head of HR is unhappy at how Colette got the position via unofficial channels, shadows her for a day and, unhappy with her handling of her staff and delicate situations, decides the Director of Nursing position must be advertised, meaning Colette will have to reapply for her own job.

She initially clashes with consultant nurse Mark Williams, though they become closer when Mark supports her during a hard day. She forgives Serena, but they decide to separate after Jason's wedding, as Serena refuses to keep Bernie from her love of adventure, while Bernie admits she can imagine Serena in a domestic setting, just not with her. Patricia Potter plays Diane Lloyd, a general surgical registrar who appears between series four, episode 39 and series nine, episode 38. Chinna Wodu plays Sean Thompson, a Senior house officer who appears in series seven from episode six until episode 43. This was part of the BBC's "Africa lives" series, a week of programmes bringing African culture to UK audiences.

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