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DES mothers should be encouraged to inform their children who had in utero exposure to DES DES daughters should have a lifetime annual gynaecological examination consisting of a general Kaufman RH, Umbach DM, Greenberg ER, : National Cancer Institute, 1995; NIH publication no. 18. Dysplasia and cytologic findings in 4,589 young women enrolled in Diethylstilbestrol-Adenosis (DESAD) Project. Increased incidence of cervical and vaginal dysplasia in 3,980 diethylstilbestrol-exposed young women. Data from several studies17,18 suggest that these women may have a higher incidence of high-grade cervical intraepithelial neoplasia, but not invasive cervical carcinoma. O’Brien PC, 32. In her book, DES Voices: From Anger to Action, DES Action Co-founder Pat Cody described the amount of DES she was given. Get Permissions, Access the latest issue of American Family Physician. Bethesda, Md. Weinberg CR, Kaufman RH. 1987;316:514–6. If DES exposure is documented or surmised from the history, counsel all of the patient’s offspring. Van Bennekom C, Role of colposcopy in the examination of diethyl-stilbestrol-exposed women. Walker BE, Interestingly, years after developing the chemical formulation for DES, its creator, Sir E. Charles Dodds was knighted for his accomplishment. DES update. et al. 15. If DES exposure is documented or surmised from the history, counsel all of the patient’s offspring. Noller KL, Anderson D, On pelvic examination, her vagina was normal, but her cervix had a pseudopolyp. Age at menarche among diethylstilbestrol granddaughters. J Urol. Two studies34,35 of “DES granddaughters”(third-generation females) have found no health effects related to DES exposure. van Gool JD, Because of the concern about a second peak in the incidence of clear cell adenocarcinoma, continued surveillance for this cancer is warranted in these women.16, Women with in utero DES exposure do not have a higher documented incidence of any other cancer. Other adverse associations have been identified in DES-exposed women and their offspring, and animal studies have shown effects in the next generation (grandchildren).5,6 The Centers for Disease Control and Prevention has instituted a campaign to educate health care professionals and patients about the risks associated with exposure to this synthetic estrogen. Adam E, Jackson R, Diethylstilbestrol revisited: a review of the long-term health effects. Structural anomalies of the cervix and vagina in women enrolled in the Diethylstilbestrol Adenosis (DESAD) Project.

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