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Medication Guide. Amgen will not sell, rent, or otherwise distribute your information outside of Amgen and related third parties. All rights reserved. The NCCN Guidelines® are a statement of consensus of its authors regarding their views of currently accepted approaches to treatment. Aranesp® is indicated for the treatment of anemia in patients with non-myeloid malignancies where anemia is due to the effect of concomitant myelosuppressive chemotherapy, and upon initiation, there is a minimum of two additional months of planned chemotherapy. This site is for use in the US only. © 2020 MJH Life Sciences™ and . No significant differences were observed between Aranesp and epoetin alfa. Any clinician seeking to apply or consult any NCCN Guidelines® is expected to use independent medical judgment in the context of individual clinical circumstances to determine any patient’s care or treatment. PRCA has also been reported in patients receiving ESAs for anemia related to hepatitis C treatment (an indication for which Aranesp, If severe anemia and low reticulocyte count develop during treatment with Aranesp, Serious allergic reactions, including anaphylactic reactions, angioedema, bronchospasm, skin rash, and urticaria may occur with Aranesp, Blistering and skin exfoliation reactions including Erythema multiforme and Stevens-Johnson Syndrome (SJS)/Toxic Epidermal Necrolysis (TEN), have been reported in patients treated with ESAs (including Aranesp. In patients with cancer receiving myelosuppressive chemotherapy in whom the anemia can be managed by transfusion. THOUSAND OAKS, California-The US Food and Drug Administration has approved Amgen’s Aranesp (darbepoetin alfa) for the treatment of chemotherapy-induced anemia in patients with nonmyeloid malignancies.

Clinical Consult: Assessing the Impact of Tailor X. The NCCN Guidelines® are a work in progress that may be refined as often as new significant data becomes available. In patients with cancer receiving myelosuppressive chemotherapy in whom the anemia can be managed by transfusion. In controlled clinical trials, ESAs increased the risk of death in patients undergoing coronary artery bypass graft surgery (CABG) and the risk of deep venous thrombosis (DVT) in patients undergoing orthopedic procedures. *Prior to treatment, inform patients of the risks and benefits of Aranesp®. As a substitute for RBC transfusions in patients who require immediate correction of anemia. This information is intended for healthcare professionals in the United States. In patients with cancer receiving myelosuppressive chemotherapy when the anticipated outcome is cure. © 2016 National Comprehensive Cancer Network, Inc. All rights reserved. Amgen will not sell, rent, or otherwise distribute your information outside of Amgen and related third parties. Prescribing Information and Medication Guide, Instructions for Use: Single-Dose Prefilled Syringe. Aranesp is used to treat anaemia in cancer patients who are receiving chemotherapy. ABBREVIATIONS:ESA = erythropoiesis-stimulating agent; EMR = electronic medical record; Hb = hemoglobin. The NCCN Guidelines® are a work in progress that may be refined as often as new significant data becomes available. Control hypertension prior to initiating and during treatment with Aranesp, For lack or loss of hemoglobin response to Aranesp, Cases of PRCA and of severe anemia, with or without other cytopenias that arise following the development of neutralizing antibodies to erythropoietin have been reported in patients treated with Aranesp.

Patients were at least 18 years of age with non-myeloid malignancies and baseline Hb ≥ 10 g/dL and < 11 g/dL on or after the start of the chemotherapy episode. Use the lowest dose of Aranesp necessary to avoid RBC transfusions. By completing and submitting this form, you agree that you would like to receive notifications of website content updates for aranesp-hcp.com. Anaemia is when your blood does not contain enough red blood cells. The National Comprehensive Cancer Network makes no warranties of any kind whatsoever regarding their content, use or application and disclaims any responsibility for their application or use in any way.

Patients could be in any cycle of their chemotherapy regimen as long as they received at least 2 additional cycles at 35-day intervals after baseline Hb measurement.

This has been reported predominantly in patients with CKD receiving ESAs by subcutaneous administration. This website is intended for U.S. healthcare professionals only. © 2018 Amgen Inc. All rights reserved. Amgen will only use the information you enter in accordance with its Privacy Policy. This information is intended for healthcare professionals in the United States. Prescribing Information and Medication Guide, Instructions for Use: Single-Dose Prefilled Syringe. Aranesp® is indicated for the treatment of anemia in patients with non-myeloid malignancies where anemia is due to the effect of concomitant myelosuppressive chemotherapy, and upon initiation, there is a minimum of two additional months of planned chemotherapy.

Aranesp is used to treat anemia caused by chemotherapy or chronic kidney disease. Aranesp is contraindicated in patients with uncontrolled hypertension. Early use of ESAs can avoid the need for red cell transfusions and maximize the effectiveness of cancer treatment.

"Aranesp not only helps correct anemia and maintain hemoglobin levels during chemotherapy, but also helps chemotherapy patients and their physicians overcome barriers that can hinder the delivery of current anemia treatment, notably the need for frequent office visits," said Robert E. Smith, Jr., MD, president of South Carolina Oncology Associates and an Aranesp investigator.

Aranesp®is indicated for the treatment of anemia in patients with non-myeloid malignancies where anemia is due to the effect of concomitant myelosuppressive chemotherapy, and upon initiation, there is a minimum of two additional months of planned chemotherapy. Erythropoietic therapies may increase the risk of thrombotic and other serious events; dose reductions are recommended if the hemoglobin increase exceeds 1.0 g/dL in any 2-week period. © 2018 Amgen Inc. All rights reserved. Data are from an aggregated US community oncology clinic electronic medical record (EMR) database of 10,523 patients (representing 10,942 chemotherapy episodes). Aranesp, a recombinant erythropoietic protein, has a half-life approximately three times longer than that of epoetin alfa (Epogen, Procrit); thus, fewer injections are required by the patient.

Control hypertension prior to initiating and during treatment with Aranesp, For lack or loss of hemoglobin response to Aranesp, Cases of PRCA and of severe anemia, with or without other cytopenias that arise following the development of neutralizing antibodies to erythropoietin have been reported in patients treated with Aranesp. PRCA has also been reported in patients receiving ESAs for anemia related to hepatitis C treatment (an indication for which Aranesp, If severe anemia and low reticulocyte count develop during treatment with Aranesp, Serious allergic reactions, including anaphylactic reactions, angioedema, bronchospasm, skin rash, and urticaria may occur with Aranesp, Blistering and skin exfoliation reactions including Erythema multiforme and Stevens-Johnson Syndrome (SJS)/Toxic Epidermal Necrolysis (TEN), have been reported in patients treated with ESAs (including Aranesp. In patients with cancer receiving hormonal agents, biologic products, or radiotherapy, unless also receiving concomitant myelosuppressive chemotherapy. Adapted with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Cancer and Chemotherapy-Induced Anemia V.2.2017.

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