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Nuclear Magnetic Resonance (NMR) Spectroscopy, Queensland Facility for Advanced Genome Editing, Queensland Facility for Advanced Bioinformatics (QFAB), Queensland Emory Drug Discovery Initiative, Clive & Vera Ramaciotti Facility for Producing Pharmaceuticals in Plants, Meet the Researchers: COVID-19 research response. We use a wide variety of techniques including molecular biology, protein X-ray crystallography, biochemical and biophysical studies of protein-protein and protein-lipid interactions, and cellular studies of protein localisation to build coherent molecular models of how molecules are trafficked within the cell. The ones marked, Molecular Trafficking Lab, The Institute for Molecular Bioscience, The, BM Collins, AJ McCoy, HM Kent, PR Evans, DJ Owen. 90 seconds with PhD student Emma Livingstone. Essential to these transport processes, says Associate Professor Brett Collins, are many different types of peripheral membrane proteins. We aim to discover their mechanisms of action and to determine their potential for therapeutic development. One focus of Associate Professor Collins’ study is the retromer complex. Professor Pete Cullen (Cell biology, University of Bristol, UK). Our scientific discoveries have been published in high impact journals including Cell, Nature, and PNAS, and was recently the subject of awards from the Australian Society for Biochemistry and Molecular Biology and the Australian New Zealand Society for Cell and Developmental Biology. Point mutations in retromer cause late-onset Parkinson’s disease, and retromer dysfunction is strongly correlated with Alzheimer’s disease. Nature, 450 7169: 570-574. doi:10.1038/nature06353. Proceedings of the National Academy of Sciences of the United States of America, 108 19: 7763-7768. doi:10.1073/pnas.1017110108, Journal Article: A SNARE-adaptor interaction is a new mode of cargo recognition in clathrin-coated vesicles, Miller, Sharon E., Collins, Brett M., McCoy, Airlie J., Robinson, Margaret S. and Owen, David J. Through study, analysis and the application of high-resolution structure determination, A/Prof Collins and his team are trying to understand these molecular mechanisms, and determine how their dysfunction contributes to disease and how to target them for new therapies. Sorting nexins are a large and diverse family of proteins with various roles in intracellular membrane transport and cell signalling. This year over 1000 National Science Week events took place across Australia including Catch a Rising Star: Women in Queensland Science, which sent teams of Queensland’s brightest early-to-mid career female scientists across the state to share their stories. Scientists from UQ’s Institute for Molecular Bioscience have peered deeper into our cell’s ‘little caves’ to better understand how our cells respond to their environment, and are affected in diseases such as cancer and muscular dystrophy. In collaboration with Prof. Their, This "Cited by" count includes citations to the following articles in Scholar. Biochemical Journal, 441 Part 1: 39-59. doi:10.1042/BJ20111226, Journal Article: Phox homology band 4.1/ezrin/radixin/moesin-like proteins function as molecular scaffolds that interact with cargo receptors and Ras GTPases, Ghai, Rajesh, Mobli, Mehdi, Norwood, Suzanne J., Bugarcic, Andrea, Teasdale, Rohan D., King, Glenn F. and Collins, Brett M. (2011) Phox homology band 4.1/ezrin/radixin/moesin-like proteins function as molecular scaffolds that interact with cargo receptors and Ras GTPases. Our body’s cells contain a dynamic system of membranes responsible for the transport of materials into, out of, and from place to place within each cell. An international team has found a way to potentially prevent the novel coronavirus from infecting cells, as well as clues as to why it is more infectious than similar viruses. He gained his Fellowship in Orthopaedics from the Royal Australasian College of Surgeons in 2009. He is a structural biologist and heads IMB’s Molecular Trafficking laboratory. Our lab has made important contributions to the molecular understanding of retromer function and continues to use the techniques of X-ray crystallography and Electron Microscopy to study the principles that govern its assembly and dysfunction. This is fundamental for normal physiology, and is important in neurodegenerative diseases including Alzheimer’s and Parkinson’s. (2007) A SNARE-adaptor interaction is a new mode of cargo recognition in clathrin-coated vesicles. University of Queensland Associate Professor Brett Collins is a group leader and a National Health and Medical Research Council (NHMRC) Career Development Fellow at the University of Queensland’s (UQ) Institute for Molecular Bioscience (IMB). Using cutting-edge structural, molecular and cellular approaches our lab aims to determine how these proteins control essential processes of cellular homeostasis, hormonal signaling, tissue morphogenesis, and neurosecretion in health and disease. Professor Robert Parton (Cell Biology, IMB, UQ), Associate Professor Rohan Teasdale (Cell Biology, SBMS, UQ), Dr Nathan Pavlos (Cell Biology, University of Western Australia), Professor Fred Meunier (Neuronal trafficking, QBI, UQ), Professor Lizzie Coulson (Mouse models of neuronal disease, SBMS, UQ), Dr Victor Anggono (Neuronal trafficking, QBI, UQ). Brett Collins Laboratory Head at University of Queensland, The Institute for Molecular Bioscience Brisbane, Australia 44 connections

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