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“The question in prosthetics is always, ‘What’s next? The trials will show if the cells repair patients’ damaged hearts without causing further damage. Until now, doctors have had limited tools to identify a second, more aggressive form of ER+/LR- that requires chemotherapy to prevent relapse. Poirier's pioneering work leads the way to successfully identifying several potent apoE inducers which are now in pre-clinical development. 'Seeds' of low-dose radioactive palladium are used to treat breast cancer patients on an outpatient basis at Sunnybrook Hospital and the Women's Research Institute in Toronto. “There’s still a lot of hard work that has to be done,” before stem cell therapy is widely used, says Dr. Michael Rudnicki, scientific director of the Canadian Stem Cell Network.

In 1959, using transistor technology, the first implantable pacemaker was developed in Sweden. Meanwhile, Nagy’s lab was perfecting a method to safely remove all trace of inserted genes, but was tripped up by having to remove four separate fragments. “I wanted the intervention to reach millions of children around the world,” says Zlotkin, who dubbed the idea Sprinkles. Developed early in the Atomic Age, this new equipment was dubbed the Cobalt Bomb, and was described as an “atomic weapon in the fight against cancer” that cost a fraction of radium of equivalent strength. A team led by Dr. Adolfo de Bold at Queen's University in Kingston discovers the cardiac hormone atrial natriuretic peptide (ANP), demonstrating that the heart is not only a pump but an endocrine organ. This included the safe cultivation of the poliovirus, using Medium 199, and an incubation process called the "Toronto Method," that increased quantities of the poliovirus for the trial. “So the thing now is, can we make use of that response in new therapeutic approaches to disease?”. “There’s lots of opportunity for development of new tracers, new radioactive materials, new treatments.”. Since then there’s been a flood of research from Chiu’s lab at McGill and that of Dr. Richard Weisel, director and senior scientist at the Toronto General Research Institute, in the transplantation of adult bone marrow stem cells in regeneration of damaged heart muscles.

This method revolutionizes genetic engineering by creating a simpler and easier way to introduce site-specific mutations into genes. Biomedical engineer Milos Popovic is generating a great deal of buzz. With breast cancer, as with most treatable cancers, relapse is the big enemy. The same year, the first medical use of radiation therapy, using the "Cobalt Bomb," happens at Victoria Hospital in London, Ontario.

Not only could the technique overcome some moral objections to using embryonic stem cells, but by using a patient’s own cells, it avoids the possibility of the cells or repaired organ being rejected by the patient’s immune system.
At three months she was fitted with her first artificial limb.

In 1949, Bigelow used a probe to prod a dog’s heart which had stopped during an operation. Inside, a small cylinder of cobalt-60 weighing mere ounces was surrounded by a lead shield. Dubbed “co-transmission,” this finding has real-world applications.

“We don’t know what causes diabetes,” says Rajotte.

Scyllo-inositol (drug candidate ELND005) is presently in Phase II clinical trials for the reduction of aggression and agitation associated with Alzheimer's Disease and mood changes in Bipolar Disorder.

Gene by gene, they built an understanding of how more than 100 different immune system genes worked.

In 1996 there were 800 new HIV cases; by 2011, only 250. From the War of 1812 to modern armed forces missions around the world, Legion Magazine offers a blend of stories, photographs, graphics, maps and posters on Canadian military history and heritage, veterans’ issues and the Canadian Armed Forces.

Membership enquiriesWilma Deen:wdeen@imc-mnc.ca613-236-0455, ext. In pharmaceutical development this technique can be used to bioengineer proteins that have specific properties or are tailored for a specific application.

We are no longer supporting IE (Internet Explorer) as we strive to provide site experiences for browsers that support new web standards and security practices. As a result, diabetes disappeared for a time in more than half of Type 1 diabetic mice, and glucose tolerance was improved for those suffering Type 2. Canadian researchers have continued to perfect methods for delivering maximum dosages to tumours, while minimizing damage to healthy tissue. Bigelow and Callaghan are also credited with sparking development of the heart pacemaker. Amazing Canadian medical discoveries 1.

The heart started up again, and Bigelow and Callaghan debated the use of other means of stimulating the heart, including electricity. This research leads to the first oral antiviral for HBV, which goes on to be used worldwide. 207, Media enquiriesSamantha Thompson:sthompson@imc-mnc.ca613-790-4555, © 2020 INNOVATIVE MEDICINES CANADA. Dr. Chiu’s own lab at McGill University Health Centre in Montreal reported the first studies on the use of stem cells for repairing damaged hearts in 1992 and 1994.

According to Canadian author Roy Mayer in his book "Inventing Canada: 100 Years of Innovation": “These two developments have had the widest influence in the field,” says Dr. Ray Chiu, professor and chair emeritus of the division of cardiothoracic surgery at McGill University in Montreal. This discovery is considered to be the most significant breakthrough in human genetics in 50 years! They are generous in sharing ideas, sharing credit for work and expressing admiration for other researchers. A study released last July confirmed that HIV-infected men and women undergoing the regime had a 95 percent lower risk of sexually transmitting the virus. And that’s just one vitamin. Researchers are also looking into using stress proteins, also called heat shock proteins because they were initially discovered following heat stress, to protect against brain damage that follows heart attack and stroke. Dr. Julio Montaner already knew the drug cocktail known as HAART (highly active antiretroviral therapy) curbed HIV symptoms. A number have refused to profit from their discoveries, preferring to share their ideas with anyone who can use them to do good. Legion Magazine is published six times a year in English with a French insert.
Using functional magnetic resonance imaging (fMRI), Gallivan and Culham were able to predict which actions the subjects intended to perform (pictured below, with images showing the subject’s point of view). Drugs using this approach are now being used to treat some kinds of leukemia. Intrigued by the pounds smokers pack on after ditching cigarettes, a neuroscientist at Ottawa’s Carleton University claims to have found the section of the brain that nicotine targets to suppress appetite. '” A biopsy proved that verdict wrong. 2007: A team led by Rob Sladek of McGill University and Génome Québec Innovation Centre identifies mutations on the four genes that increase risk of developing Type 2 diabetes. Legion Magazine engages Canadians in commemorating the effort, bravery and sacrifice of those who served and continue to serve in Canada’s military. PHOTO: COURTESY OF UNIVERSITY HEALTH NETWORK, PHOTO: CHRIS LUND/NATIONAL FILM BOARD OF CANADA/LIBRARY AND ARCHIVES CANADA–PA-116671. Email the writer at: writer@legionmagazine.com, Email a letter to the editor at: letters@legionmagazine.com. Drug and insecticide- resistance makes eliminating the disease challenging.

In order to understand how this system works, Mak’s team developed mice with one specific immune system gene knocked out. Using positional cloning, Dr. Lap-Chee Tsui and a team of scientists from the Hospital for Sick Children in Toronto discover the gene and molecular defect responsible for cystic fibrosis. Dr. Jack Hirsh, from McMaster University, observes the relationship between the in vitro anticoagulant activity of heparin and its ability to treat venous thrombosis (blood clots in veins). And if your immune system mistakes a pathogen for a part of the body, you’re dead.”Mak, now director of the Campbell Family Institute for Breast Cancer at Toronto’s Princess Margaret Hospital, has taken two other byways during his long career. Two genes are involved in the function of beta cells in the pancreas, which make insulin. Today there are only about 100 cases of rickets yearly in Canada.Development of Pablum is important for two reasons, says Zlotkin. However, one form of a breast cancer, ER+/LR- (estrogen receptor positive/lymph node negative), has a low risk of relapse. Canada gets a big bang for its research bucks: although it ranks 14th in research spending among 31 Western industrialized nations, it ranks sixth in producing top research papers.

They enlisted Jack Hopps, an electrical engineer with the National Research Council in Ottawa, who developed the external pacemaker, soon adopted in many hospitals. And Dr. Wilfred Bigelow’s work on hypothermia was initially given a very cold shoulder by fellow physicians.

He and other researchers used viruses to insert these four genes into adult cells from skin. An exciting benefit of this research is that there is now a formula to engineer the precise type and ratio of cardiac cell types to produce functional human heart micro-tissues that can be used to measure normal and diseased human heart responses to drugs. The first was the discovery, in the 1840s, of anesthetic, which rendered surgery painless. The world's first commercial therapeutic application of nanotechnology is invented by Dr. Robert Burrell at the University of Alberta.

The compound, later identified as dicoumoral, leads the way to the discovery of vitamin K inhibitors, which prevent blood from clotting during surgery as well as prevent strokes and heart attacks caused by blood clots. Understanding the behaviour of this second neurotransmitter in Parkinson sufferers could lead to better-targeted medications for those with the disease. Quebec becomes the first province to add Vitamin D to milk, based on the research and advocacy of Montreal pediatrician and geneticist Dr. Charles Scriver, who discovered hereditary forms of rickets in children. It could also be more economical. It’s exciting to imagine how these kinds of Canadian medical breakthroughs might improve millions of lives. Researchers do not live in ivory towers. Image courtesy of the National Institute on Aging/National Institutes of Health. But when the data started rolling in, Montaner – today the director of the BC Centre for Excellence in HIV/AIDS – was surprised: Transmission rates in British Columbia were dropping.

He is hopeful the test could reach the market in as little as three years. The list of Canadian medical breakthroughs measures in the hundreds, if not thousands, and includes every field of medical endeavour, from developing drugs and vaccines to designing medical equipment, inventing new surgical and treatment techniques, finding causes of diseases, identifying genes whose defects cause disease, pioneering cell-based therapy—and many, many more.

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